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All in the Genes

People do not “catch” an autoinflammatory disease, but carry the potential for one in their genes.

Although the mechanism of NOMID is not completely understood, it is believed that symptoms are mostly the result of gene mutations a person is born with, which makes these conditions hard to diagnose. In about 60% of patients with NOMID, the gene that encodes a protein called cryopyrin is not working correctly. This damaged protein causes the immune system to react with general inflammation, even though no harm has come to the body from outside.

Does NOMID Run in Families?

Not really. Most patients with NOMID, the most severe form of CAPS, have no family history. But other autoinflammatory diseases are usually passed on from parent to child. However, as in NOMID, people with no CAPS family connection can still have it. Also, not everyone with CAPS in the family necessarily gets one of the diseases.

Autoinflammatory vs Autoimmune Disorders: What’s the Difference?

It is easy to confuse these conditions because they all cause inflammation. The main difference is that they activate 2 distinct types of immune systems in our bodies.

In autoinflammatory diseases, the “innate” system–the one we are born with–is tricked by genetic mutations to attack our tissues. In autoimmune diseases, however, it is the “acquired’ system that becomes damaged. This system works by “acquiring memories” of the “bad” substances we come across as we grow up. That way it learns to fight only those when they come back. But in autoimmune diseases, the system has acquired the “wrong memories” and attacks the naturally good substances in our tissues as if they were bad.

The common thread in these types of disorders is a malfunctioning immune system. In many cases, symptoms of these conditions have been linked to the same process affected by the important protein interleukin-1 (IL-1). IL-1 plays a pivotal role in the inflammation associated with NOMID.

Click on Glossary to learn words related to NOMID, and Kineret. You will also find a selection of Online Resources with information about these rare syndromes.

Kineret® Helps Reduce
NOMID Symptoms

Patients in studies reported significant improvment with Kineret

More About Kineret Results

A NOMID Journey: Quinn

Learn about one child's diagnosisand how the family manages their symptoms

Watch Quinn's Story


Kineret® is a prescription medicine called an interleukin-1 receptor antagonist (IL-1ra) used to:

Kineret is not for children with Juvenile Rheumatoid Arthritis


Do not take Kineret if you are allergic to:

Before you use Kineret, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.Kineret and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) Blockers. Ask your healthcare provider for a list of these medicines if you are not sure.

Kineret may cause serious side effects, including:

The most common side effects of Kineret for RA include: 


The most common side effects of Kineret for NOMID include:

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of Kineret. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information