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Managing Injection Site Reactions

Help to Relieve Injection Discomfort

About 25% of patients in the clinical trial experienced a reaction at the injection site. The site reactions you can expect with a Kineret injection are skin-related but they could make injections challenging during the first month. They include redness, swelling, bruising, itching, and stinging. Most of these side effects are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID.

These tips may help lessen reactions at the injection site:

Cool The Site

  • Place a cold compress or gel pack on the site a few minutes before and after the injection

Warm Kineret to Room Temperature

  • Do not skip taking Kineret out of the refrigerator and leaving it at room temperature for 30 minutes before your injection
  • Never try to accelerate the warm-up by placing the syringe in hot water or in a microwave. This will destroy the active medicine
  • Make sure the needle tip is dry before inserting into the skin

Care For The Skin

  • Rotate sites to avoid soreness. You can consider using a diary to help you keep track
  • Do not inject on damaged skin: red, bruised, tender, swollen, or hard
  • Avoid areas of skin with scars or stretch marks
  • Do not inject Kineret close to a vein that you can see under the surface of your skin

Additional Resources

For more on easing injection site pain and the complete injection process, download the Kineret Patient/Caregiver Guide

You may also download Healthier Ever After, a booklet with tips about injections, site reactions, and other topics gathered by a leading nonprofit organization and members of the autoinflammatory disease community.

Ask your doctor about any injection site reactions and side effects, especially if they keep coming back or become bothersome. You can also call 866-773-5274 and speak with our medical staff about these and any other treatment-related topics. Line is open Mondays to Fridays, from 9 AM – 5 PM, Eastern Time.


Kineret® is a prescription medicine called an interleukin-1 receptor antagonist (IL-1ra) used to:

Kineret is not for children with Juvenile Rheumatoid Arthritis


Do not take Kineret if you are allergic to:

Before you use Kineret, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.Kineret and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) Blockers. Ask your healthcare provider for a list of these medicines if you are not sure.

Kineret may cause serious side effects, including:

The most common side effects of Kineret for RA include: 


The most common side effects of Kineret for NOMID include:

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of Kineret. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information