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KINERET® (anakinra) is a prescription medicine called an interleukin-1 receptor antagonist (IL-1Ra) used to:
RA: Reduce the signs and symptoms and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people aged 18 years and older when 1 or more other drugs for RA have not worked
NOMID: Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)
DIRA: Treat people with Deficiency of Interleukin-1 Receptor Antagonist (DIRA)
KINERET is not for children with Juvenile Rheumatoid Arthritis.
Do not take KINERET if you are allergic to:
Before starting KINERET, tell your healthcare provider if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
KINERET and other medicines may affect each other and cause serious side effects. Especially, tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) blockers. Ask your healthcare provider for a list of these medicines if you are not sure. Know the medications you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new prescription.
KINERET may cause serious side effects, including:
Serious infections. KINERET may lower your ability to fight infections. During treatment with KINERET, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use KINERET. You should not receive live vaccines while you use KINERET
Allergic reactions. Stop using KINERET and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating. People with DIRA may have an increased risk of allergic reactions, especially in the first several weeks
Decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like KINERET, affect your risk of getting cancer
Low white blood cell count (neutropenia). KINERET may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with KINERET, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year
The most common side effects of KINERET include:
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all of the possible side effects of KINERET. For more information ask your healthcare provider or pharmacist. You can also see the Full Prescribing Information for KINERET including Patient Information and Instructions for Use at https://www.kineretrx.com/pdf/Full-Prescribing-Information-English.pdf
To report suspected side effects, contact Sobi North America at 1-866-773-5274 or FDA at 1-800-FDA-1088
Click here for full Prescribing Information for KINERET, including Patient Information.
This information is intended for US healthcare professionals. Please confirm you are a healthcare professional to continue.