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Taking Kineret® 

Taking Kineret®

Kineret® should be injected under the skin by the patient or caregiver. It is important to receive appropriate instructions from your healthcare provider on how to inject, how often to inject Kineret, and the correct way to dispose of used syringes.

Each Kineret® dose comes in a prefilled glass syringe. Kineret® is available in 2 quantities: a 28-pack, and a convenient 7-pack, with 7 syringes in each box, one for each day of the week. Use the Kineret® prefilled syringe that matches the day of the week until 7 are used.

Important Safety Information

DO NOT FREEZE OR SHAKE KINERET®. Keep Kineret® away from light. Store Kineret in its original carton in the refrigerator at 36 °F to 46 °F (2 °C to 8 °C). When traveling, make sure you store Kineret at the correct temperature.  Safely dispose of Kineret that is out of date or no longer needed.  Keep it out of the reach of children.


When taking Kineret®, always use a new syringe each day.

• Take Kineret® exactly as instructed by your healthcare provider

• If you have a kidney problem, your healthcare provider may need to change how often you take your injections.

• Take Kineret at about the same time each day, on a schedule that works best for you

• If you drop a syringe, do not use the syringe. Dispose of the syringe and replace it with a new one.

• If you miss a dose, contact your healthcare provider to find out when to take your next injection

• Only you and your healthcare provider can determine how well Kineret is working for you. The time it takes to see improvement in symptoms varies from person to person

Next: Administration


What to expect 
when starting Kineret®

Be in the know – with tips for your Kineret treatment experience.

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Kineret® is a prescription medicine called an interleukin-1 receptor antagonist (IL-1ra) used to:

  • Reduce the signs and symptoms, and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people age 18 years and older when 1 or more other drugs for RA have not worked
  • Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Kineret is not for children with Juvenile Rheumatoid Arthritis


Do not take Kineret if you are allergic to:

  • proteins made from bacteria called E. coli. Ask your healthcare provider if you are not sure
  • anakinra or any of the ingredients in Kineret. See the end of the patient leaflet for a complete list of ingredients in Kineret

Before you use Kineret, tell your healthcare provider if you:

  • have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections
  • have an allergy to rubber or latex. The inner needle cover on the prefilled syringe contains latex. Do not handle the needle cover if you are allergic to latex
  • have kidney problems
  • are scheduled to receive any vaccines. People using Kineret should not receive live vaccines
  • are pregnant or plan to become pregnant. It is not known if Kineret will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if Kineret passes into your breast milk. You and your healthcare provider should decide if you will take Kineret or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.Kineret and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) Blockers. Ask your healthcare provider for a list of these medicines if you are not sure.

Kineret may cause serious side effects, including:

  • serious infections. Kineret may lower your ability to fight infections. During treatment with Kineret, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use Kineret. You should not receive live vaccines while you use Kineret.
  • allergic reactions. Stop using Kineret and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating.
  • decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like Kineret, affect your risk of getting cancer.
  • low white blood cell count (neutropenia). Kineret may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with Kineret, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year.

The most common side effects of Kineret for RA include:

  • injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days
  • rheumatoid arthritis (RA) gets worse with treatment
  • sore throat or runny nose
  • headache
  • nausea
  • diarrhea
  • sinus infection
  • joint pain
  • feeling like you have the flu
  • pain in your stomach area

The most common side effects of Kineret for NOMID include:

  • injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID
  • headache
  • vomiting
  • joint pain
  • fever
  • feeling like you have the flu
  • sore throat or runny nose

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of Kineret. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information