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Administering
Kineret® 

It is important to receive appropriate instruction from your healthcare provider before taking Kineret® for the first time. Take Kineret® exactly as instructed by your healthcare provider.

The instructions outlined here do not take the place of talking with your healthcare provider.

Setting up for Injection

Steps to prepare and give an injection of Kineret®

1. Find a clean, flat work surface, such as a table.

2. Assemble the following supplies:

  • One alcohol swab
  • A dry gauze or cotton ball
  • Kineret® prefilled syringe
  • A puncture-resistant container

3. Take the carton containing the prefilled syringes of Kineret® out of the refrigerator.

  • Remove the prefilled syringe from the box that matches the day of the week
  • Return the carton containing the remaining prefilled syringes to the refrigerator


4. Check the expiration date on the syringe label. If the expiration date has passed, do not use the syringe. Contact your pharmacist or call 1-866-Kineret (1-866-546-3738) for assistance.

5. Let the Kineret® solution warm to room temperature for 30 minutes prior to injection. Do not remove the needle cover during this process.

6. Do not shake the prefilled syringe. If the solution is foamy, allow the prefilled syringe to sit for a few minutes until it clears.

7. Make sure the solution in the prefilled syringe is clear and colorless. You may see a small amount of tiny particles that are white, or that you can see through. These particles come from the protein in Kineret® and are okay.

  • Do not inject the solution if it is cloudy or discolored, or has large or colored particles
  • Call your healthcare provider or pharmacist if you have any questions about a Kineret® prefilled syringe


8. Wash your hands with soap and warm water.

 

Please see full Prescribing Information

Preparing the Injection Site

Selecting and preparing the injection site

1. Choose an injection site. Recommended injection sites include:

·         The outer area of the upper arms

·         The abdomen (except within a 2-inch area around the navel) 

·         The front of the middle thighs

·         The upper outer areas of the buttocks 

 


2. Choose a new site each time you use Kineret.

·         Choosing a new site may help avoid soreness at any one site

·         Do not inject Kineret into an area that is tender red, bruised, or hard

·         Avoid areas with scars or stretch marks

·         Do not inject close to a vein that you can see under the surface of your skin

 

3. Clean the injection site with an alcohol swab.

·         Let the area dry completely

·         Injecting through a site that is still moist from an alcohol swab may cause stinging

 

Please see full Prescribing Information.

Administering the Injection

Administering the Injection

1. Pick up the prefilled syringe from your clean, flat, work surface.

  • Hold the syringe in the hand you will use to inject Kineret®
  • Remove the needle cover. The needle cover on the prefilled syringe contains latex. Do not handle the needle cover if you are allergic to latex.
  • Twisting the needle cover while pulling will help in the removal.
  • Do not touch the needle or allow it to touch any surface.

 

You may notice a small air bubble in the prefilled syringe.

  • You do not have to remove the air bubble.
  • Injecting the solution with the air bubble is harmless
  • The area should always be dry during the injection

 

2. With your free hand, gently pinch a fold of skin
    at the cleaned injection site.

 

3. Hold the syringe (like a pencil) at a
    45 to 90 degree angle to the skin.

·         With a quick, dart-like motion, insert the
          needle into the skin

 

4. After the needle is inserted‚ gently let go of the skin. Pull the plunger back slightly. If no blood appears in the syringe, slowly push the plunger all the way down to inject Kineret®.

• If blood comes into the syringe, do not inject Kineret®, because the needle has entered a blood vessel.

·         Withdraw the needle

• Dispose of the used prefilled Kineret® syringe in a puncture-resistant container

• Prepare a new injection site and use a new prefilled syringe

 

5. When the syringe is empty, pull the needle out of the skin, being careful to keep it at the same angle as inserted.

 

6. Place a cotton ball or gauze over the injection site and press for several seconds.

·         Do not use an alcohol swab as it may cause stinging

·         If there is a little bleeding, you may cover the injection site with a small bandage

Disposing of Syringes and Supplies

Disposing of Syringes and Supplies


The syringes should NEVER be reused. NEVER recap a needle.

  • Place the used syringe in a puncture-resistant container and talk to your healthcare provider or pharmacist about how to properly dispose of your used syringes.

You can also download a pdf of the patient brochure which contains information on:

Setting up for injection

Preparing the injection site

Administering the injection

Managing injection site reactions

 

Next: What to Expect

 

What to expect 
when starting Kineret®

Be in the know – with tips for your Kineret treatment experience.

Get tips

INDICATIONS

Kineret® is a prescription medicine called an interleukin-1 receptor antagonist (IL-1ra) used to:

  • Reduce the signs and symptoms, and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people age 18 years and older when 1 or more other drugs for RA have not worked
  • Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Kineret is not for children with Juvenile Rheumatoid Arthritis

IMPORTANT SAFETY INFORMATION

Do not take Kineret if you are allergic to:

  • proteins made from bacteria called E. coli. Ask your healthcare provider if you are not sure
  • anakinra or any of the ingredients in Kineret. See the end of the patient leaflet for a complete list of ingredients in Kineret

Before you use Kineret, tell your healthcare provider if you:

  • have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections
  • have an allergy to rubber or latex. The inner needle cover on the prefilled syringe contains latex. Do not handle the needle cover if you are allergic to latex
  • have kidney problems
  • are scheduled to receive any vaccines. People using Kineret should not receive live vaccines
  • are pregnant or plan to become pregnant. It is not known if Kineret will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if Kineret passes into your breast milk. You and your healthcare provider should decide if you will take Kineret or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.Kineret and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) Blockers. Ask your healthcare provider for a list of these medicines if you are not sure.

Kineret may cause serious side effects, including:

  • serious infections. Kineret may lower your ability to fight infections. During treatment with Kineret, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use Kineret. You should not receive live vaccines while you use Kineret.
  • allergic reactions. Stop using Kineret and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating.
  • decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like Kineret, affect your risk of getting cancer.
  • low white blood cell count (neutropenia). Kineret may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with Kineret, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year.

The most common side effects of Kineret for RA include:

  • injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days
  • rheumatoid arthritis (RA) gets worse with treatment
  • sore throat or runny nose
  • headache
  • nausea
  • diarrhea
  • sinus infection
  • joint pain
  • feeling like you have the flu
  • pain in your stomach area

The most common side effects of Kineret for NOMID include:

  • injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID
  • headache
  • vomiting
  • joint pain
  • fever
  • feeling like you have the flu
  • sore throat or runny nose

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of Kineret. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information