Full Prescribing Information and Instructions for Use
ENGLISH ESPAÑOL
For Healthcare Professionals
Kineret for NOMID Patient Stories Using Kineret KINERET® On TRACK Resources Kineret for RA Patient Stories Using Kineret KINERET® On TRACK Resources

How should I inject Kineret?

Learn from your healthcare team and develop a routine.

Whether this is your first time injecting or you have used different injection therapies, every treatment is different and we recommend you take advantage of Kineret injection training resources.

The nurses at your doctor’s office may train you to inject or you can receive injection training at any time from the trained nurses at KINERET® On TRACK.

Watch the Kineret injection video

What happens if I have an injection site reaction?

Most injection site reactions are temporary, and there are tips to help address them.

  • Skin reactions are the most common side effect with Kineret and may appear as redness, swelling, bruising, itching, or stinging of the skin at the injection site
  • Injection site skin reactions are most common during the first month of treatment and usually last about 14 to 28 days

To help address injection site reactions:

  • Cool the site with a cold compress or ice pack for a few minutes, both before and after the injection
  • Don't skip the warm-up step of bringing Kineret to room temperature
  • Apply hydrocortisone or an antihistamine cream to your injection site
  • Rotate sites to avoid soreness. A diary or the Kineret Injection Tracker can help keep track of sites
  • Don't inject into skin that is red, bruised, tender, or hard

How do I get Kineret?

KINERET On TRACK will arrange for Kineret to be shipped directly to your home.

Kineret is supplied in single-use, prefilled, graduated glass syringes containing 100 mg of Kineret solution. Kineret is dispensed in a 7-day pack and most people receive their Kineret in a shipment of 4 packs (containing a total of 28 injections).

How should I store Kineret?

Kineret should be stored in a refrigerator.

Kineret should be refrigerated at between 36°F to 46°F (2°C to 8°C).

no-sun

Store Kineret in its original carton and away from light.

twelve-hours

Discard any syringe that has been left out of the refrigerator for more than 12 hours.*

temp

Do not freeze or shake Kineret.

*We recommend you take your Kineret syringe out of the refrigerator to allow it to warm to room temperature before injection.

What injection resources are available?

The following resources contain information about injection training.

As a complement to the initial injection instructions you may receive from your doctor’s office, these Kineret training materials contain information that can help you get started.

If you would like to request in-home injection training or get advice via telephone from a Kineret Trained Nurse, KINERET On TRACK may be able to help.

Kineret® (anakinra) Injection Tracker

A printable sheet for keeping track of your injection sites

Kineret Treatment Guide

A brochure with information about how Kineret works, how to store and inject Kineret, and details about the services of KINERET On TRACK

Kineret Instructions for Use

Instructions for storing and injecting Kineret

If you would like to request in-home injection training or get advice via telephone from a Kineret Trained Nurse, KINERET On TRACK may be able to help.

Learn more about the services of KINERET On TRACK

INDICATIONS

Kineret® is a prescription medicine called an interleukin-1 receptor antagonist (IL-1ra) used to:

  • Reduce the signs and symptoms, and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people age 18 years and older when 1 or more other drugs for RA have not worked
  • Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

IMPORTANT SAFETY INFORMATION

Who should not take Kineret?

People who are allergic to:

  • proteins made from bacteria called E. coli. Ask your healthcare provider if you are not sure
  • anakinra or any of the ingredients in Kineret. See the end of the patient leaflet for a complete list of ingredients in Kineret

What information should I know before starting Kineret?

Before you use Kineret, tell your healthcare provider if you:

  • have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections
  • have kidney problem
  • are scheduled to receive any vaccines. People using Kineret should not receive live vaccines
  • are pregnant or plan to become pregnant. It is not known if Kineret will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if Kineret passes into your breast milk. You and your healthcare provider should decide if you will use Kineret or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Kineret and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) Blockers. Ask your healthcare provider for a list of these medicines if you are not sure.

What are the possible side effects of Kineret?

Kineret may cause serious side effects, including:

  • serious infections. Kineret may lower your ability to fight infections. During treatment with Kineret, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use Kineret. You should not receive live vaccines while you use Kineret.
  • allergic reactions. Stop using Kineret and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injections site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating.
  • decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like Kineret, affect your risk of getting cancer.
  • low white blood cell count (neutropenia). Kineret may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with Kineret, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year.

The most common side effects of Kineret for RA include:

  • Injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days
  • rheumatoid arthritis (RA) gets worse with treatment
  • sore throat or runny nose
  • headache
  • nausea
  • diarrhea
  • sinus infection
  • joint pain
  • feeling like you have the flu
  • pain in your stomach area

The most common side effects of Kineret for NOMID include:

  • Injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID
  • headache
  • vomiting
  • diarrhea
  • joint pain
  • fever
  • feeling like you have the flu
  • sore throat or runny nose

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of Kineret. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information.