The KINERET logo and generic name (anakinra)

KINERET Support Program

How should I inject KINERET?

Learn from your healthcare team and develop a routine.

When your child starts KINERET treatment, you will receive injection training from the professionals at your hospital or doctor's office. Then the time will come for you to continue with daily KINERET injections at home.

Whether you are a parent injecting your child or a patient learning to self-inject, it is important to learn the correct way to safely handle syringes and to give injections so you can gain the confidence you need.

Watch the KINERET injection video

What happens if my child has an injection site reaction?

Most injection site reactions are temporary, and there are tips to help address them.

  • Skin reactions are the most common side effect with KINERET and may appear as redness, swelling, bruising, itching, or stinging of the skin at the injection site
  • Injection site skin reactions are most common during the first month of treatment and usually last about 14 to 28 days

To help address injection site reactions:

  • Cool the site with a cold compress or ice pack for a few minutes, both before and after the injection
  • Don't skip the warm-up step of bringing KINERET to room temperature
  • Apply hydrocortisone or an antihistamine cream to your injection site
  • Rotate sites to avoid soreness. A diary or the KINERET Injection Tracker can help keep track of sites
  • Don't inject into skin that is red, bruised, tender, or hard

How do I get KINERET?

Kineret ON TRACK™ will arrange for KINERET to be shipped directly to your home.

KINERET is supplied in single-use, prefilled, graduated glass syringes containing 100 mg of KINERET solution. KINERET is dispensed in a 7-day pack and most people receive their KINERET in a shipment of 4 packs (containing a total of 28 injections), but this may vary depending on your prescription.

KINERET syringe and packaging

How should I store KINERET?

KINERET should be stored in a refrigerator.

KINERET should be refrigerated at between 36°F to 46°F (2°C to 8°C).

Store KINERET in its original carton and away from light.

Discard any syringe that has been left out of the refrigerator for more than 12 hours.*

Do not freeze or shake KINERET.

*We recommend you take your KINERET syringe out of the refrigerator to allow it to warm to room temperature before injection.

What injection resources are available?

A variety of resources contain information on injecting KINERET.

As a complement to the initial injection instructions you may receive from your doctor's office, you can use these KINERET training materials to help you get started.

If you would like to request in-home injection training or get advice via telephone from a KINERET Trained Nurse, Kineret ON TRACK™ may be able to help.

KINERET® (anakinra) injection tracker

A printable sheet for keeping track of your injection sites

KINERET treatment guide

A brochure with information about how KINERET works, how to store and inject KINERET, and details about the services of Kineret ON TRACK™

KINERET instructions for use

Instructions for storing and injecting KINERET

The Kineret ON TRACK™ logo and generic name (anakinra)

If you would like to request in-home injection training or get advice via telephone from a KINERET Trained Nurse, Kineret ON TRACK™ may be able to help.

Learn more about the services of Kineret ON TRACK™


KINERET® (anakinra) is a prescription medicine called an interleukin-1 receptor antagonist (IL-1Ra) used to:

RA: Reduce the signs and symptoms and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people aged 18 years and older when 1 or more other drugs for RA have not worked

NOMID: Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

DIRA: Treat people with Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

KINERET is not for children with Juvenile Rheumatoid Arthritis.


Do not take KINERET if you are allergic to:

  • Proteins made from bacteria called E. coli. Ask your healthcare provider if you are not sure
  • Anakinra or any of the ingredients in KINERET. See the end of the patient leaflet for a complete list of ingredients in KINERET

Before starting KINERET, tell your healthcare provider if you:

  • Have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections
  • Are scheduled to receive any vaccines. People using KINERET should not receive live vaccines
  • Have kidney problems
  • Are pregnant or plan to become pregnant. It is not known if KINERET will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KINERET passes into your breast milk. You and your healthcare provider should decide if you will use KINERET or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

KINERET and other medicines may affect each other and cause serious side effects. Especially, tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) blockers. Ask your healthcare provider for a list of these medicines if you are not sure. Know the medications you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new prescription.

KINERET may cause serious side effects, including:

Serious infections. KINERET may lower your ability to fight infections. During treatment with KINERET, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use KINERET. You should not receive live vaccines while you use KINERET

Allergic reactions. Stop using KINERET and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating. People with DIRA may have an increased risk of allergic reactions, especially in the first several weeks

Decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like KINERET, affect your risk of getting cancer

Low white blood cell count (neutropenia). KINERET may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with KINERET, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year

The most common side effects of KINERET include:

  • Injection site skin reactions. The symptoms of injection site skin reactions may include: redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID
  • RA gets worse with treatment, if you already have RA
  • Headache
  • Nausea and vomiting
  • Diarrhea
  • Joint pain
  • Fever
  • Feeling like you have the flu
  • Sore throat or runny nose
  • Sinus infection
  • Pain in your stomach area

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects of KINERET. For more information ask your healthcare provider or pharmacist. You can also see the Full Prescribing Information for KINERET including Patient Information and Instructions for Use at

To report suspected side effects, contact Sobi North America at 1-866-773-5274 or FDA at 1-800-FDA-1088

Click here for full Prescribing Information for KINERET, including Patient Information.