The KINERET logo and generic name (anakinra)

KINERET Support Program

Megan was diagnosed with RA in 2011 at age 31.

"Suddenly, halfway through my PhD program, I was blindsided by a sudden and unexpected illness: fever, rashes, pain that crept up every limb from the throbbing joints in my hand and feet and prevented me from doing the most basic of tasks."—Megan, RA patient

Woman heading to work

Before starting KINERET, Megan tried multiple RA treatments, all of which failed.

"I spent two years trying and failing multiple RA drugs, never knowing which drug might treat some symptoms but exacerbate others. […] I began to feel that my rheumatologist and I were firing shots into the air and hoping we hit something."—Megan, RA patient

Based on Megan's history of IL-1–driven inflammatory RA symptoms, her rheumatologist prescribed KINERET.

"Knowing my history of RA symptoms, my rheumatologist chose to start me on KINERET, and I will be forever grateful for her insight."—Megan, RA patient

Woman sitting outside writing in a journal

Megan responded well to KINERET and had a reduction in symptoms within the first 12 weeks.

"Compared to how I felt when I was diagnosed, and during the three years after, the change is heartening."—Megan, RA patient

Megan continues to work closely with her doctor to manage injection site reactions.

"I've found letting the solution warm up, and injecting slowly in a relaxed position (for example, sitting up in bed) is the best way for me to manage them."—Megan, RA patient

Woman on the phone

KINERET® On TRACK has supported Megan throughout her KINERET treatment.

"KINERET On TRACK allowed me to work with a case manager and get KINERET sent right to my office."—Megan, RA patient


KINERET® (anakinra) is a prescription medicine called an interleukin-1 receptor antagonist (IL-1Ra) used to:

  • Reduce the signs and symptoms and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people aged 18 years and older when 1 or more other drugs for RA have not worked
  • Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-Onset Multisystem Inflammatory Disease (NOMID)
  • Treat people with Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

KINERET is not for children with Juvenile Rheumatoid Arthritis.


Who should not take KINERET?

People who are allergic to:

  • Proteins made from bacteria called E. coli. Ask your healthcare provider if you are not sure
  • Anakinra or any of the ingredients in KINERET. See the end of the patient leaflet for a complete list of ingredients in KINERET

What information should I know before starting KINERET?

Before you use KINERET, tell your healthcare provider if you:

  • Have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections
  • Are scheduled to receive any vaccines. People using KINERET should not receive live vaccines
  • Have kidney problems
  • Are pregnant or plan to become pregnant. It is not known if KINERET will harm your unborn baby
  • Are breastfeeding or plan to breastfeed. It is not known if KINERET passes into your breast milk. You and your healthcare provider should decide if you will use KINERET or breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KINERET and other medicines may affect each other and cause serious side effects. Especially tell your healthcare provider if you take certain other medicines that affect your immune system called Tumor Necrosis Factor (TNF) blockers. Ask your healthcare provider for a list of these medicines if you are not sure. Know the medications you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new prescription.

What are the possible side effects of KINERET?

KINERET may cause serious side effects, including:

  • Serious infections. KINERET may lower your ability to fight infections. During treatment with KINERET, call your healthcare provider right away if you get an infection, have any sign of an infection including a fever or chills, or have any open sores on your body. You may get an infection if you receive live vaccines while you use KINERET. You should not receive live vaccines while you use KINERET
  • Allergic reactions. Stop using KINERET and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating. People with DIRA may have an increased risk of allergic reactions, especially in the first several weeks
  • Decreased ability of your body to fight infections (immunosuppression). It is not known if treatment with medicines that cause immunosuppression, like KINERET, affect your risk of getting cancer
  • Low white blood cell count (neutropenia). KINERET may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with KINERET, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year

The most common side effects of KINERET include:

  • Injection site skin reactions, including redness, swelling, bruising, itching, and stinging. Most injection site reactions are mild, happen early during treatment, and last about 14 to 28 days. Injection site reactions have been observed less frequently in people with NOMID
  • RA gets worse with treatment, if you already have RA
  • Headache
  • Nausea and vomiting
  • Diarrhea
  • Joint pain
  • Fever
  • Feeling like you have the flu
  • Sore throat or runny nose
  • Sinus infection
  • Pain in your stomach area

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of KINERET. For more information ask your healthcare provider or pharmacist.

Please see full Prescribing Information, including Patient Information.